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1. CN111617108 - Application of postsynaptic neurotoxin, cardiotoxin, cytotoxin, phospholipase A2 and crude venom of cobra in resisting virus infection

Office
China
Application Number 202010623330.1
Application Date 29.06.2020
Publication Number 111617108
Publication Date 04.09.2020
Publication Kind A
IPC
A61K 35/583
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
58Reptiles
583Snakes; Lizards, e.g. chameleons
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 38/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61K 35/583
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
58Reptiles
583Snakes; Lizards, e.g. chameleons
A61K 38/1703
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
1703from vertebrates
A61K 38/465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
465acting on ester bonds (3.1), e.g. lipases, ribonucleases
C12Y 301/01004
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
301Hydrolases acting on ester bonds (3.1)
01Carboxylic ester hydrolases (3.1.1)
01004Phospholipase A2 (3.1.1.4)
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
Applicants SHEN ZHEJING
沈喆景
Inventors SHEN ZHEJING
沈喆景
Title
(EN) Application of postsynaptic neurotoxin, cardiotoxin, cytotoxin, phospholipase A2 and crude venom of cobra in resisting virus infection
(ZH) 眼镜蛇科蛇突触后神经毒素、心脏毒素、细胞毒素、磷脂酶A2及粗毒在抗病毒感染上的应用
Abstract
(EN) The invention relates to application of a postsynaptic neurotoxin, a cardiotoxin, a cytotoxin, a phospholipase A2 and a crude venom of a cobra in resisting virus infection. A respiratory tract is easily invaded and infected by viruses due to an open anatomical structure to the outside, and viral influenza and pneumonia are relatively common cases in daily life; and in addition, hepatitis B virusesand AIDS viruses can infect human beings to cause diseases through various ways. The current treatment means of respiratory diseases caused by viruses is not ideal in vaccine or drug effect, and thetreatment effect of viral hepatitis and AIDS needs to be further improved, so that a product which has broad-spectrum inhibition capacity on viruses and has small side effect is developed to become aclinical urgent need. The postsynaptic neurotoxin, the cardiotoxin, the cytotoxin, the phospholipase A2 and the crude venom of the cobra show the effectiveness in resisting virus infection, and possibly become a candidate of a new antiviral product.
(ZH) 本发明涉及眼镜蛇科蛇突触后神经毒素、心脏毒素、细胞毒素、磷脂酶A2及粗毒在抗病毒感染上的应用。呼吸道由于它对外界开放式的解剖结构而容易受到病毒的侵袭和感染,病毒性流感和肺炎是日常生活中比较常见的病例;除此以外,乙肝病毒、艾滋病毒也会通过多种途径感染人类致病。病毒性引起的呼吸道疾病目前的治疗手段无论是疫苗还是药物效果都不太理想,病毒性肝炎和艾滋病的治疗效果也有待进一步提高,故开发一种对病毒具有广谱抑制能力而副作用小的产品已成为一种临床急需。眼镜蛇科蛇突触后神经毒素、心脏毒素、细胞毒素、磷脂酶A2及粗毒都显示出其在抗病毒感染上的有效性,有可能成为新的抗病毒产品的候选者。
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