(EN) Provided is a novel composition. A composition for cytotoxic T cell depletion, the composition including an anti-LAG-3 antibody or a binding fragment thereof that has the properties described in (i) to (iii): (i) has in vitro ADCC activity; (ii) reduces the number of LAG-3-positive cells in vivo in low-fucose form; and (iii) binds to human activated T cells.
(ZH) 提供了新型组合物。用于细胞毒性T细胞耗竭的组合物，所述组合物包含具有以下(i)至(iii)中描述的特性的抗LAG‑3抗体或其结合片段：(i)具有体外ADCC活性；(ii)以低岩藻糖形式减少体内LAG‑3阳性细胞的数量；和(iii)结合人活化的T细胞。
