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1. CN111406755 - Camellia nitidissima theaflavin medicament for resisting novel coronavirus and preparation method and application thereof

Office
China
Application Number 202010239403.7
Application Date 30.03.2020
Publication Number 111406755
Publication Date 14.07.2020
Publication Kind A
IPC
A01N 47/44
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
47Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
40the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
42containing -N=CX2 groups, e.g. isothiourea
44Guanidine; Derivatives thereof
A01N 43/16
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04with one hetero atom
14six-membered rings
16with oxygen as the ring hetero atom
A01P 1/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
1Disinfectants; Antimicrobial compounds or mixtures thereof
A61K 31/353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/785
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
785Polymers containing nitrogen
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A01N 47/44
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
47Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
40the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
42containing —N=CX2 groups, e.g. isothiourea
44Guanidine; Derivatives thereof
A01N 43/16
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
04with one hetero atom
14six-membered rings
16with oxygen as the ring hetero atom
A61K 31/353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/785
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
74Synthetic polymeric materials
785Polymers containing nitrogen
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 31/455
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
Applicants SHAOGUAN UNIVERSITY
韶关学院
Inventors CHENG JINSHENG
程金生
WAN WEIHONG
万维宏
Agents 广州骏思知识产权代理有限公司 44425
Title
(EN) Camellia nitidissima theaflavin medicament for resisting novel coronavirus and preparation method and application thereof
(ZH) 一种抗新型冠状病毒的金花茶茶黄素药剂及其制备方法和应用
Abstract
(EN) The invention provides a camellia nitidissima theaflavin medicament for resisting novel coronavirus. The formula comprises the following raw materials in parts by mass: 20-60 parts of camellia nitidissima theaflavin-3-monogallate, 20-60 parts of camellia nitidissima theaflavin-3, 3'-digallate, 3-8 parts of hyaluronic acid, 8-20 parts of nicotinamide, 15-30 parts of ceramide, 3-10 parts of pyruvicacid, 12-30 parts of sodium pyruvate, 3-8 parts of polyhexamethylene guanidine, 5-15 parts of Tween, 150-500 parts of glycerol and 15-35 parts of paraben. Compared with the prior art, camellia nitidissima theaflavin-3-monogallate and camellia nitidissima theaflavin-3, 3'-digallate are mixed uniformly; and 3, 3'-digallate is used as a main active component, the activity of reverse transcriptase ofRNA viruses can be effectively inhibited, then the purpose of killing novel coronaviruses is achieved, hyaluronic acid, nicotinamide, ceramide, glycerol and other components are further matched, the nourishing and fine line removing effects are remarkable, and the medicament is very suitable for being applied to the surface of human skin.
(ZH) 本发明提供了一种抗新型冠状病毒的金花茶茶黄素药剂,包括以下按质量份数计原料:金花茶茶黄素‑3‑单没食子酸酯20‑60份,金花茶茶黄素‑3,3’‑双没食子酸酯20‑60份,透明质酸3‑8份,烟酰胺8‑20份,神经酰胺15‑30份,丙酮酸3‑10份,丙酮酸钠12‑30份,聚六亚甲基胍3‑8份、吐温5‑15份、甘油150‑500份,对羟基苯甲酸酯15‑35份。相对于现有技术,本发明将金花茶茶黄素‑3‑单没食子酸酯和金花茶茶黄素‑3,3’‑双没食子酸酯作为主要活性成分,能有效抑制RNA病毒的逆转录酶的活性,进而达到灭杀新型冠状病毒的目的,同时,本发明还配合了透明质酸、烟酰胺、神经酰胺、甘油等成分,滋养、去细纹效果显著,非常适合将该药剂应用于人体皮肤表面。
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