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1. CN111233927 - 硫胺类化合物、制备方法及其药物组合物

Office China
Application Number 201910592261.X
Application Date 03.07.2019
Publication Number 111233927
Publication Date 05.06.2020
Publication Kind A
IPC
C07F 9/6512
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645having two nitrogen atoms as the only ring hetero atoms
6509Six-membered rings
6512having the nitrogen atoms in positions 1 and 3
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61K 31/675
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
675having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A61P 39/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
06Free radical scavengers or antioxidants
Applicants 上海日馨生物科技有限公司
Inventors 钟春玖
张寰
Agents 北京集佳知识产权代理有限公司 11227
Priority Data 201811469330X 28.11.2018 CN
Title
(ZH) 硫胺类化合物、制备方法及其药物组合物
Abstract
(ZH)
本发明的具体实施方式提供一种硫胺类化合物、制备方法及其药物组合物,所述化合物对Aβ40和/或Aβ42具有抑制作用,特别当与其连接的苯乙烯基的苯环未取代、或卤素原子取代时,其化合物对Aβ40和Aβ42均有突出的抑制作用。

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