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1. CN111217828 - 一种乐平霉素的制备方法及其中间体

Office China
Application Number 201811416685.2
Application Date 26.11.2018
Publication Number 111217828
Publication Date 02.06.2020
Publication Kind A
IPC
C07D 493/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
Applicants 浙江海正药业股份有限公司
Inventors 张绍勇
王继栋
张辉
李建宋
齐欢
滕云
白骅
Title
(ZH) 一种乐平霉素的制备方法及其中间体
Abstract
(ZH)
本发明公开了一种式V所示的乐平霉素的制备方法及其中间体,以天维菌素为起始原料,分别经过酸水解反应,5位羟基上保护基,然后与2‑甲氧亚氨基苯乙酸经过SN2反应,最后脱除5位羟基保护基得到式V化合物。本发明具有成本低,纯度高,收率高和适合工业化生产的优点。

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