(EN) Provided is a compound useful as a cathepsin S inhibitor. The present inventors have studied on a compound which has a cathepsin S-inhibiting activity and can be used as an active ingredient for a pharmaceutical composition for preventing and/or treating an autoimmune disease such as systemic lupus erythematosus (SLE) and lupus nephritis, an allergy, or organ, bone marrow or tissue graft rejection. As a result, it has been confirmed that a phenyldifluoromethyl-substituted prolineamide compound according to the present invention has a cathepsin S-inhibiting activity. This confirmation leads to the accomplishment of the present invention. The phenyldifluoromethyl-substituted prolineamide compound according to the present invention has a cathepsin S-inhibiting activity, and can be used as a prophylactic and/or therapeutic agent for an autoimmune disease such as SLE and nephritis, an allergy, or organ, bone marrow or tissue graft rejection.
(ZH) 提供了一种用作组织蛋白酶S抑制剂的化合物。本发明人研究了具有组织蛋白酶S抑制作用且可作为用于预防和/或治疗包括系统性红斑狼疮(SLE)和狼疮性肾炎的自身免疫性疾病、过敏症、或者器官、骨髓或组织的移植物排斥的医药组合物的有效成分的化合物，确认本发明的苯基二氟甲基取代脯氨酰胺化合物具有组织蛋白酶S抑制作用，从而完成了本发明。本发明的苯基二氟甲基取代脯氨酰胺化合物具有组织蛋白酶S抑制作用，可以用作包括SLE和肾炎的自身免疫性疾病、过敏症、或者器官、骨髓或组织的移植物排斥的预防和/或治疗剂。
