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1. CN109521038 - Method for selectively detecting dopamine based on magnetic resonance nuclear spin singlet state

Office China
Application Number 201811450785.7
Application Date 30.11.2018
Publication Number 109521038
Publication Date 26.03.2019
Publication Kind A
IPC
G01N 24/08
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
24Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
08by using nuclear magnetic resonance
CPC
G01N 24/087
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
24Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
08by using nuclear magnetic resonance
087Structure determination of a chemical compound, e.g. of a biomolecule such as a protein
Applicants EAST CHINA NORMAL UNIVERSITY
华东师范大学
Inventors XIN JIAXIANG
辛家祥
LIU HUIXIA
刘慧霞
WEI DAXIU
魏达秀
YAO YEFENG
姚叶锋
Agents 上海蓝迪专利商标事务所(普通合伙) 31215
上海蓝迪专利商标事务所(普通合伙) 31215
Title
(EN) Method for selectively detecting dopamine based on magnetic resonance nuclear spin singlet state
(ZH) 一种基于磁共振核自旋单态选择性检测多巴胺的方法
Abstract
(EN)
The invention discloses a method for selectively detecting dopamine based on a magnetic resonance nuclear spin singlet state. According to the method provided by the invention, a dopamine signal is selectively detected in a complicated system by utilizing a nuclear spin singlet state of three hydrogen atoms on a dopamine benzene ring. The method is used for detecting the dopamine based on magneticresonance, has very good accuracy, sensitivity and selectivity and can be used for accurately detecting the complicated system of components to obtain a dopamine signal so that the interference of other substance signals are eliminated very well. Meanwhile, the method disclosed by the invention has the advantages of simplicity in operation, no pains and noninvasiveness, can be used for monitoringthe content and distribution of the dopamine in a living body and has important application value in the fields of biology and medicine.

(ZH)
本发明公开了一种基于磁共振核自旋单态选择性检测多巴胺的方法,该方法利用多巴胺苯环上三个氢的核自旋单态实现在复杂体系中对多巴胺信号的选择性检测。本发明基于磁共振检测多巴胺,具有很好地精确度、灵敏度和选择性,能够准确的从组成成分复杂的体系中检测得到多巴胺的信号,很好地消除其它物质信号的干扰。同时,本发明还具有操作简单、无痛无创的优势,可用于监控活体内多巴胺的含量和分布,在生物学、医学领域具有重要的应用价值。

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