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1. CN109456968 - Tumor marker STAMP-EP5 based on methylation modification

Office China
Application Number 201811634957.6
Application Date 29.12.2018
Publication Number 109456968
Publication Date 12.03.2019
Publication Kind A
IPC
C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/154
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
154Methylation markers
Applicants SHANGHAI EPIPROBE BIOTECHNOLOGY CO., LTD.
上海奕谱生物科技有限公司
Inventors LI ZHENYAN
李振艳
LUO HUAIBING
罗怀兵
Agents 上海专利商标事务所有限公司 31100
Title
(EN) Tumor marker STAMP-EP5 based on methylation modification
(ZH) 基于甲基化修饰的肿瘤标记物STAMP-EP5
Abstract
(EN)
The invention provides a methylation tumor marker STAMP-EP5 and application thereof and belongs to the field of disease diagnosis markers. The invention provides the application of the methylation tumor marker STAMP-EP5 to preparation of tumor diagnosis reagents. The tumor marker STAMP-EP5 provided by the invention shows high methylation in all tumor types and low methylation in corresponding normal tissues, and has extremely high sensitivity and specificity; a primer for detecting the STAMP-EP5 can be used for preparing a tumor diagnosis kit.

(ZH)
本发明提供了一种甲基化肿瘤标志物STAMP‑EP5及其应用,属于疾病诊断标记物领域。本发明提供了甲基化肿瘤标志物STAMP‑EP5在制备肿瘤诊断试剂中的应用。本发明所述肿瘤标志物STAMP‑EP5,在所有肿瘤类型中均高甲基化,对应的正常组织中均低甲基化,具有非常高的敏感性与特异性,检测所述STAMP‑EP5的引物可用于制备肿瘤诊断试剂盒。

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