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1. CN109371138 - Methylated modification based tumor marker STAMP (specific tumor aligned methylation of pan-cancer)-EP4

Office
China
Application Number 201811634286.3
Application Date 29.12.2018
Publication Number 109371138
Publication Date 22.02.2019
Publication Kind A
IPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/154
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
154Methylation markers
Applicants SHANGHAI EPIPROBE BIO-TECH CO., LTD.
上海奕谱生物科技有限公司
Inventors LI ZHENYAN
李振艳
LUO HUAIBING
罗怀兵
Agents 上海专利商标事务所有限公司 31100
Title
(EN) Methylated modification based tumor marker STAMP (specific tumor aligned methylation of pan-cancer)-EP4
(ZH) 基于甲基化修饰的肿瘤标记物STAMP-EP4
Abstract
(EN)
The invention provides a methylated modification based tumor marker STAMP (specific tumor aligned methylation of pan-cancer)-EP4 and an application thereof, belongs to the field of disease diagnosis markers, and provides an application of the methylated modification based tumor marker STAMP-EP4 to preparation of a tumor diagnosis reagent. The tumor marker STAMP-EP4 is hypermethylated in all tumortypes and hypomethylated in corresponding normal tissue and has quite high sensitivity and specificity, and STAMP-EP4 detection primers can be used for preparing a tumor diagnosis kit.

(ZH)
本发明提供了一种甲基化肿瘤标志物STAMP‑EP4及其应用,属于疾病诊断标记物领域。本发明提供了甲基化肿瘤标志物STAMP‑EP4在制备肿瘤诊断试剂中的应用。本发明所述肿瘤标志物STAMP‑EP4,在所有肿瘤类型中均高甲基化,对应的正常组织中均低甲基化,具有非常高的敏感性与特异性,检测所述STAMP‑EP4的引物可用于制备肿瘤诊断试剂盒。

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