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1. CN109153073 - PROCESS FOR THE PREPARATION OF HOLLOW NANOPARTICLES WITH A METAL CORE

Office
China
Application Number 201780027826.9
Application Date 10.05.2017
Publication Number 109153073
Publication Date 04.01.2019
Grant Number 109153073
Grant Date 25.08.2020
Publication Kind B
IPC
B22F 1/00
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
1Special treatment of metallic powder, e.g. to facilitate working, to improve properties; Metallic powders per se, e.g. mixtures of particles of different composition
B22F 1/02
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
1Special treatment of metallic powder, e.g. to facilitate working, to improve properties; Metallic powders per se, e.g. mixtures of particles of different composition
02comprising coating of the powder
B22F 9/24
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
9Making metallic powder or suspensions thereof; Apparatus or devices specially adapted therefor
16using chemical processes
18with reduction of metal compounds
24starting from liquid metal compounds, e.g. solutions
C01B 33/18
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
33Silicon; Compounds thereof
113Silicon oxides; Hydrates thereof
12Silica; Hydrates thereof, e.g. lepidoic silicic acid
18Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 49/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
CPC
A61K 41/0038
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
A61K 49/183
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
183having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
A61K 49/1866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1866the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
A61K 49/225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
225Microparticles, microcapsules
B22F 1/0018
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
1Special treatment of metallic powder, e.g. to facilitate working, to improve properties
0003Metallic powders per se; Mixtures of metallic powders; Metallic powders mixed with a lubricating or binding agent
0007Metallic powder characterised by its shape or structure, e.g. fibre structure
0011Metallic powder characterised by size or surface area only
0018Nanometer sized particles
B22F 1/02
BPERFORMING OPERATIONS; TRANSPORTING
22CASTING; POWDER METALLURGY
FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
1Special treatment of metallic powder, e.g. to facilitate working, to improve properties
02comprising coating of the powder
Applicants FONDAZIONE ST ITALIANO DI TECNOLOGIA
意大利学院科技基金会
Inventors VOLIANI VALERIO
瓦莱利奥·瓦利安尼
Agents 北京商专永信知识产权代理事务所(普通合伙) 11400
北京商专永信知识产权代理事务所(普通合伙) 11400
Title
(EN) PROCESS FOR THE PREPARATION OF HOLLOW NANOPARTICLES WITH A METAL CORE
(ZH) 制备具有金属核的中空纳米颗粒的方法
Abstract
(EN)
The present invention relates to silica hollow nanoparticles having inside their cavity a metal core consisting of inorganic nanostructures coated by a protective agent and agglomerated with a polymeric aggregating agent, useful in particular in medicine in the bio-imaging techniques and/or in the radio-therapeutic or chemo-therapeutic techniques; the invention moreover refers to a process for thepreparation of such nanoparticles.

(ZH)
本发明涉及二氧化硅中空纳米颗粒,其空腔内具有金属核,该金属核由无机纳米结构组成,该无机纳米结构涂覆有保护剂并与聚合物聚集剂聚集,其特别适用于医学中生物成像技术医学和/或放疗或化疗技术;本发明还涉及制备该纳米颗粒的方法。