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1. (CN109072248) METHODS AND COMPOSITIONS FOR INCREASING EFFICIENCY OF TARGETED GENE MODIFICATION USING OLIGONUCLEOTIDE-MEDIATED GENE REPAIR

Office : China
Application Number: 201680084442.6 Application Date: 16.09.2016
Publication Number: 109072248 Publication Date: 21.12.2018
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2016052346 ; Publication Number: Click to see the data
IPC:
C12N 15/82
C12N 5/10
A01H 5/00
A01H 6/20
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
82
for plant cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
H
NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
5
Flowering plants, i.e. angiosperms
[IPC code unknown for A01H 6/20]
CPC:
C12N 15/8213
C12N 5/04
C12N 15/8275
C12N 2310/20
C12N 2310/321
Applicants: CIBUS US LLC
希博斯美国有限公司
CIBUS EUROPE B.V.
希博斯欧洲有限公司
Inventors: BEETHAM PETER R.
P·R·比瑟姆
GOCAL GREGORY F. W.
G·F·W·格卡尔
SCHOPKE CHRISTIAN
C·施波克
SAUER NOEL
N·萨奥尔
PEARCE JAMES
J·皮尔斯
SEGAMI ROSA E.
R·E·塞格米
MOZORUK JERRY
J·莫左鲁克
Agents: 北京市铸成律师事务所 11313
北京市铸成律师事务所 11313
Priority Data: 62/293,278 09.02.2016 US
Title: (EN) METHODS AND COMPOSITIONS FOR INCREASING EFFICIENCY OF TARGETED GENE MODIFICATION USING OLIGONUCLEOTIDE-MEDIATED GENE REPAIR
(ZH) 采用寡核苷酸介导的基因修复提高靶向基因修饰的效率的方法和组合物
Abstract: front page image
(EN) The present invention provides methods and compositions for making targeted changes to a DNA sequence. In various aspects and embodiments, methods and compositions for modifying a DNA sequence in a cell (such as a plant, bacterial, yeast, fungal, algal, or mammalian cell) are provided. In some aspects and embodiments the modification of DNA involves combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms, such as a DNA cutter.
(ZH) 本文所提供的包括用于对DNA序列进行靶向改变的方法和组合物。在各种方面和实施方案中,提供用于修饰细胞(如植物、细菌、酵母、真菌、藻类或哺乳动物细胞)中的DNA序列的方法和组合物。在一些方面和实施方案中,DNA的修饰涉及将基因修复寡核苷酸与增强靶细胞基因修复机制的组分(如DNA切割体)的可用性的方法相结合。
Also published as:
CA3014036KR1020180116769IN201827033800BR112018016278EA201891629WO/2017/138986