(EN) The invention relates to Eribulin intermediates and a preparation method thereof. Particularly, the invention relates to compound shown in a formula II, formula III and formula V, wherein Ar is a C1-10 alkyl substituted or alkyloxy substituted or unsubstituted aryl group, R1 and R2 are aldehyde acetal protecting groups or thioacetal protecting groups, R3 is hydrogen or a hydroxy protecting group,and X is halogen or a leaving group. The invention particularly relates to the preparation method of the compounds shown in the formula II, formula III and formula V. The preparation method has the advantages of mild reaction conditions, high selectivity, easy purification, low synthesis cost and the like, and is suitable for large-scale production.
(ZH) 本发明涉及一种艾日布林中间体及其制备方法。具体而言,本发明涉及一种如式II、式III和式V所示的化合物,其中,Ar为C1‑10烷基取代或烷基氧基取代或非取代的芳基;R1,R2为缩醛保护基团或者硫缩醛保护基团;R3为氢或者羟基保护基;X为卤素或者离去基团。本发明还特别涉及一种如式II、式III和式V所示的化合物的制备方法,该方法具有反应条件温和,选择性高,易于纯化,合成成本低廉等优点,适于大规模生产。