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1. (CN108602833) TLR7 agonist trifluoroacetate salt and crystalline form B thereof, preparation methods and uses

Office : China
Application Number: 201780009751.1 Application Date: 04.02.2017
Publication Number: 108602833 Publication Date: 28.09.2018
Publication Kind : A
Prior PCT appl.: Application Number:PCTCN2017072894 ; Publication Number: Click to see the data
IPC:
C07D 487/04
A61K 31/519
A61P 31/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
正大天晴药业集团股份有限公司
Inventors: DING ZHAOZHONG
丁照中
SUN FEI
孙飞
HU YINGHU
胡迎虎
ZHOU YILONG
周义龙
WANG ZHENG
王峥
ZHAO RUI
赵锐
YANG LING
杨玲
Priority Data: 2016100818993 05.02.2016 CN
Title: (EN) TLR7 agonist trifluoroacetate salt and crystalline form B thereof, preparation methods and uses
(ZH) 一种TLR7激动剂的三氟乙酸盐、晶型B、制备方法和用途
Abstract:
(EN) The present invention relates to a trifluoroacetate salt of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), crystalline form B of the trifluoroacetate salt, methods for preparing the trifluoroacetate salt and crystalline form B, and uses of the trifluoroacetate salt and crystalline form B.
(ZH) 本发明涉及一种TLR7激动剂2‑丁氧基‑7‑(4‑(吡咯烷‑1‑基甲基)苄基)‑5H‑吡咯并[3,2‑d]嘧啶‑4‑胺(式I)的三氟乙酸盐、其晶型B、其制备方法和用途。
Also published as:
UAa201809128AU2017214135CA3013521MYPI 2018702700SG11201806688QKR1020180104118
EP3412674IL260981BR112018015878US20190031666IN201817032726EA201891772
ID2018/12857PH1/2018/501641WO/2017/133687