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1. CN108601806 - BOTANICAL COMPOSITIONS OF SALVIA OFFICINALIS WITH ACTIVITY IN EXTENDING CHRONOLOGICAL LIFESPAN AND METHODS OF USE

Office
China
Application Number 201780008300.6
Application Date 27.01.2017
Publication Number 108601806
Publication Date 28.09.2018
Publication Kind A
IPC
A61K 36/537
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
537Salvia (sage)
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 36/537
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
537Salvia (sage)
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39General protective or antinoxious agents
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 49/0008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
0008Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
Applicants SIBELIUS LTD
西贝柳斯有限公司
Inventors LEYLAND PETER ANTHONY
P·A·莱兰
AKOULITCHEV ALEXANDRE
A·阿库里奇
VERSLYPE ANTOINE
A·沃斯莱普
CAIGER STEPHEN
S·凯杰
Agents 隆天知识产权代理有限公司 72003
隆天知识产权代理有限公司 72003
Priority Data 1601520.8 27.01.2016 GB
Title
(EN) BOTANICAL COMPOSITIONS OF SALVIA OFFICINALIS WITH ACTIVITY IN EXTENDING CHRONOLOGICAL LIFESPAN AND METHODS OF USE
(ZH) 具有延长时序寿命活性的药用鼠尾草的植物组合物及使用方法
Abstract
(EN) Compositions comprising a nutritionally or pharmaceutically effective dosage of an extract of Salvia officinalis and an acceptable carrier are provided. The compositions show particular potential in the treatment of age-related pathologies in humans or animals. The extracts are obtained from varieties and cultivars of Salvia officinalis that possess a unique chemical fingerprint that includes unusually low thujone content in the leaf. When tested in C. elegans screening assays compositions that comprise the extract elicit an increase in mean chronological lifespan (CLS) in the C. elegans population of at least 10%.
(ZH) 提供了组合物,其包含营养学或药学有效剂量的药用鼠尾草提取物和可接受的载体。该组合物在治疗人或动物的年龄相关的病状方面表现出特别的潜力。提取物从药用鼠尾草的品种和栽培品种获得,这些品种和栽培品种具有独特的化学指纹,其包括叶中异常低的侧柏酮含量。当在秀丽隐杆线虫筛选测定中测试时,包含提取物的组合物引起秀丽隐杆线虫种群中平均时序寿命(CLS)增加至少10%。