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1. CN108503560 - Osalmid crystal form II, and preparation method and application thereof

Office
China
Application Number 201710108969.4
Application Date 27.02.2017
Publication Number 108503560
Publication Date 07.09.2018
Grant Number 108503560
Grant Date 25.05.2021
Publication Kind B
IPC
C07C 235/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
58with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring
64having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 231/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
22Separation; Purification; Stabilisation; Use of additives
24Separation; Purification
CPC
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 231/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
22Separation; Purification; Stabilisation; Use of additives
24Separation; Purification
C07C 235/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
58with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
64having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 231/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
08from amides by reaction at nitrogen atoms of carboxamide groups
Applicants SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
中国科学院上海药物研究所
Inventors ZHU WEILIANG
朱维良
XU ZHIJIAN
徐志建
LI BO
李波
ZHANG YONG
张勇
Agents 北京金信知识产权代理有限公司 11225
北京金信知识产权代理有限公司 11225
Title
(EN) Osalmid crystal form II, and preparation method and application thereof
(ZH) 柳胺酚晶型II、其制备方法及其应用
Abstract
(EN) The invention disclose an osalmid crystal form II, and a preparation method and application thereof. In the XRPD pattern of the crystal form expressed by 2theta angles, characteristic peaks occur whendiffraction angles are 7.527+/-0.2 DEG, 13.653+/-0.2 DEG, 14.644+/-0.2 DEG, 15.037+/-0.2 DEG, 19.62+/-0.2 DEG, 20.092+/-0.2 DEG, 20.454+/-0.2 DEG, 22.618+/-0.2 DEG, 24.45+/-0.2 DEG, 25.226+/-0.2 DEG,26.288+/-0.2 DEG, 26.638+/-0.2 DEG, 28.516+/-0.2 DEG, 29.373+/-0.2 DEG, 29.723+/-0.2 DEG, 31.605+/-0.2 DEG, 35.794+/-0.2 DEG and 38.104+/-0.2 DEG. The crystal form has excellent physical and chemicalproperties and drug-forming properties, is simple to prepare and low in hygroscopicity, and shows good stability and reproducibility.
(ZH) 公开了柳胺酚晶型II、其制备方法及其应用。该晶型以2θ角度表示的XRPD在衍射角7.527±0.2、13.653±0.2、14.644±0.2、15.037±0.2、19.62±0.2、20.092±0.2、20.454±0.2、22.618±0.2、24.45±0.2、25.226±0.2、26.288±0.2、26.638±0.2、28.516±0.2、29.373±0.2、29.723±0.2、31.605±0.2、35.794±0.2、38.104±0.2处具有特征峰。该晶型具有优良的理化性质和成药性能,制备方法简单,晶型吸湿性小,具有良好的稳定性,重现性好能。
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