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1. (CN108473468) INHIBITORS OF RET

Office : China
Application Number: 201680076816.X Application Date: 01.11.2016
Publication Number: 108473468 Publication Date: 31.08.2018
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2016059879 ; Publication Number: Click to see the data
IPC:
C07D 401/14
C07D 403/14
A61P 35/00
A61K 31/53
A61K 31/506
A61K 31/4439
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
CPC:
C07D 401/14
C07D 403/14
A61K 31/4439
A61K 31/506
A61P 35/00
Applicants: BLUEPRINT MEDICINES CORP
蓝图药品公司
Inventors: BRUBAKER JASON D
J·D·布鲁贝克
KIM JOSEPH L
J·L·基姆
WILSON KEVIN J
K·J·威尔逊
WILSON DOUGLAS
D·威尔逊
DIPIETRO LUCIAN V
L·V·迪比特罗
Agents: 永新专利商标代理有限公司 72002
Priority Data: 62/249,784 02.11.2015 US
62/367,960 28.07.2016 US
Title: (EN) INHIBITORS OF RET
(ZH) RET的抑制剂
Abstract:
(EN) Inhibitors of wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
(ZH) 本文提供野生型RET及其抗性突变体的抑制剂、包含所述化合物的药物组合物、以及使用所述化合物和组合物的方法。
Also published as:
AU2016348402CA3003721SG11201803653QMYPI 2018701728KR1020180073689EP3371171
IN201817018952PH1/2018/500907BR112018008877EA201891087WO/2017/079140