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1. CN108291230 - 3' UTR SEQUENCES FOR STABILIZATION OF RNA

Office
China
Application Number 201680058612.3
Application Date 05.10.2016
Publication Number 108291230
Publication Date 17.07.2018
Publication Kind A
IPC
C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants BIONTECH RNA PHARMACEUTICALS GMBH
生物技术RNA制药有限公司
TRON-TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GGMBH
约翰·古腾堡大学美因兹医学大学转化肿瘤学公司
Inventors ORLANDINI VON NIESSEN ALEXANDRA
亚历山德拉·奥兰迪尼冯尼森
FESSER STEPHANIE
斯特凡妮·费塞尔
VALLAZZA BRITTA
布丽塔·瓦拉扎
BEISSERT TIM
蒂姆·拜塞特
KUHN ANDREAS
安德烈亚斯·库恩
SAHIN UGUR
乌尔·沙欣
POLEGANOV MARCO ALEXANDER
马尔科·亚历山大·波莱加诺夫
Agents 北京集佳知识产权代理有限公司 11227
北京集佳知识产权代理有限公司 11227
Priority Data PCT/EP2015/073180 07.10.2015 EP
Title
(EN) 3' UTR SEQUENCES FOR STABILIZATION OF RNA
(ZH) 用于使RNA稳定的3’UTR序列
Abstract
(EN)
The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.

(ZH)
本发明涉及RNA、特别是mRNA的稳定化以及mRNA翻译的提高。本发明特别地涉及RNA、特别是体外转录RNA的修饰,其导致提高的转录物稳定性和/或翻译效率。根据本发明,其表明了在RNA分子的3’‑非翻译区(UTR)的某些序列提高稳定性和翻译效率。