CN108137659 Peptide having effect of preventing or treating central nervous system diseases and pharmaceutical composition for preventing and treating central nervous system diseases, containing same as active ingredient

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Application Number 201680056710.3

Application Date 19.08.2016

Publication Number 108137659

Publication Date 08.06.2018

Grant Number 108137659

Grant Date 26.11.2021

Publication Kind B

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Applicants INDUSTRY-UNIVERSITY COOP FOUND HANYANG UNIVERSITY
汉阳大学校产学协力团

Inventors CHOI JE-MIN
崔济民
LIM SANGHO
林相昊

Agents 北京集佳知识产权代理有限公司 11227
北京集佳知识产权代理有限公司 11227

Priority Data 10-2015-0117966 21.08.2015 KR

Title

(EN) Peptide having effect of preventing or treating central nervous system diseases and pharmaceutical composition for preventing and treating central nervous system diseases, containing same as active ingredient

(ZH) 具有预防或治疗中枢神经系统疾病作用的肽和包含其作为活性成分的药物组合物

Abstract

(EN) The present invention has a function of enabling the penetration of the blood-brain barrier and the blood-spinal cord barrier of the central nervous system, which have not been significantly penetrated, with excellent efficiency, thereby enabling a rapid, quick, and more efficient therapeutic effect to be obtained through low dose administration. In addition, the present invention enables local administration unlike conventional therapeutic agents, thereby decreasing side effects, and enables local administration of a therapeutic agent at a high concentration, thereby enabling potentially newtreatments and prescriptions.

(ZH) 本发明具有能够以优异效率渗透未曾显著渗透的中枢神经系统的血脑屏障和血脊髓屏障的功能，由此能够通过低剂量施用获得迅速、快速且更加有效的治疗效果。此外，本发明能够实现不同于常规治疗剂的局部施用，从而减少副作用，并且能够以高浓度局部施用治疗剂，从而潜在地能够实现新的治疗和处方。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
16	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17	from animals; from humans

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
19	Hybrid peptides

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans

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1. CN108137659 - Peptide having effect of preventing or treating central nervous system diseases and pharmaceutical composition for preventing and treating central nervous system diseases, containing same as active ingredient

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes; Proenzymes; Compositions thereof
10	Transferases (2.)
1025	Acyltransferases (2.3)
104	Aminoacyltransferases (2.3.2)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2319	Fusion polypeptide
01	containing a localisation/targetting motif
10	containing a tag for extracellular membrane crossing, e.g. TAT or VP22

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2319	Fusion polypeptide
01	containing a localisation/targetting motif
10	containing a tag for extracellular membrane crossing, e.g. TAT or VP22

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
001	Preparation for luminescence or biological staining
0013	Luminescence
0017	Fluorescence in vivo
0019	characterised by the fluorescent group
0045	the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
0047	Green fluorescent protein [GFP]

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent