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1. CN107582589 - Gynura formosana Kitam. total flavonoids extract, preparation method thereof, and applications of gynura formosana Kitam. total flavonoids extract in treating hyperuricemia

Office China
Application Number 201710841633.9
Application Date 18.09.2017
Publication Number 107582589
Publication Date 16.01.2018
Publication Kind A
IPC
A61K 36/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61P 19/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
CPC
A61K 36/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61P 19/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
06Antigout agents, e.g. antihyperuricemic or uricosuric agents
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
B01D 15/08
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
Applicants ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD.
Inventors YUAN HUIJUN
YIN TINGTING
HONG FEI
YU JUAN
ZENG JINXIANG
WANG SHICONG
Title
(EN) Gynura formosana Kitam. total flavonoids extract, preparation method thereof, and applications of gynura formosana Kitam. total flavonoids extract in treating hyperuricemia
(ZH) 一种白凤菜总黄酮提取物及其制备方法与治疗高尿酸血症的用途
Abstract
(EN)
The invention belongs to the field of drug or health care product, and more specifically relates to a gynura formosana Kitam. total flavonoids extract, a preparation method thereof, and applications of the gynura formosana Kitam. total flavonoids extract in treating hyperuricemia. The gynura formosana Kitam. total flavonoids extract comprises, by weight, 80 to 85% of rutin. It is shown by drug effect experiment results that the gynura formosana Kitam. total flavonoids extract is capable of reducing the activity of xanthine oxidase in the livers of hyperuricemia mouse models and inhibiting systhesis of uric acid at a certain degree, and reducing uric acid at a certain degree, and can be taken as a potential drug used for treating hyperuricemia or gout. According to the preparation method, after extraction, a composite enzyme is composed of enzymes of specific composition and specific ratio, and is used for enzymatic hydrolysis; and in addition, macroporous resin extraction condensationand macroporous resin separation purifying are adopted. The HPLC purity of rutin in the gynura formosana Kitam. total flavonoids extract is capable of reaching 80 to 85%.

(ZH)
本发明属于药品或保健品领域,具体涉及一种白凤菜总黄酮提取物及其制备方法与治疗高尿酸血症的用途。该提取物中,以重量百分含量计,含有80~85%的芦丁。药效实验结果表明,该提取物可以在一定程度上降低高尿酸血症模型小鼠肝脏内黄嘌呤氧化酶的活性、降低尿酸的合成,具有一定的降尿酸作用,可以作为潜在的治疗高尿酸血症或治疗痛风的药物;本发明白凤菜总黄酮提取物的制备方法,在提取步骤后,通过选择特定组成、特定配比的酶组成的复合酶进行酶解,进一步通过大孔树脂萃取浓缩和大孔树脂分离纯化步骤,使得制备得到的白凤菜总黄酮提取物中芦丁的HPLC纯度可达80~85%。

Also published as
JP2020537273