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1. CN106943124 - Quantification of local circulation with OCT angiography

Office
China
Application Number 201610894427.X
Application Date 10.09.2013
Publication Number 106943124
Publication Date 14.07.2017
Grant Number 106943124
Grant Date 07.07.2020
Publication Kind B
IPC
A61B 5/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
A61B 5/026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026Measuring blood flow
A61B 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
A61B 3/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
12for looking at the eye fundus, e.g. ophthalmoscopes
G06T 7/00
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7Image analysis
CPC
A61B 3/0025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
0016Operational features thereof
0025characterised by electronic signal processing, e.g. eye models
A61B 3/102
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
102for optical coherence tomography [OCT]
A61B 3/1241
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
12for looking at the eye fundus, e.g. ophthalmoscopes
1241specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
A61B 5/0066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0062Arrangements for scanning
0066Optical coherence imaging
A61B 5/02007
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
02007Evaluating blood vessel condition, e.g. elasticity, compliance
A61B 5/0261
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
026Measuring blood flow
0261using optical means, e.g. infra-red light
Applicants OREGON HEALTH & SCIENCE UNIVERSITY
俄勒冈健康科学大学
Inventors HUANG DAVID
大卫·黄
JIA YALI
贾雅莉
TOKAYER JASON
贾森·托考耶
TAN OU
谭鸥
Agents 北京市磐华律师事务所 11336
北京市磐华律师事务所 11336
Priority Data 61/699,257 10.09.2012 US
61/799,502 15.03.2013 US
Title
(EN) Quantification of local circulation with OCT angiography
(ZH) 用光学相干断层扫描血管造影对局部循环进行量化
Abstract
(EN) Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.
(ZH) 在人眼中血管床内的眼内血液流动的减少与某些眼部疾病相关联,所述眼部疾病例如包括青光眼、糖尿病性视网膜病变和年龄相关性黄斑变性。用于对各种眼内血管床的一个或多个中的血液流动量化的可靠方法可提供对眼部疾病病理生理学的血管组成的深入了解。利用超高速光学相干断层扫描(OCT),开发出用于对不同眼内区域内的微循环进行成像的一种称为频谱分离幅度去相关血管造影(SSADA)的新的3D血管造影算法,所述眼内区域例如包括眼部视盘,颞椭圆,视乳头周围视网膜,视乳头周围脉络膜,黄斑视网膜,黄斑脉络膜,视网膜中央凹无血管区,以及无灌注区域。如本文所述,用于量化SSADA结果的方法被开发出来并用于检测早期眼部疾病中灌注的变化。本文还描述了与用于定量测量在不同眼内血管部位处的血液流动的方法相关的相关联实施例,用于实施这种方法的系统,以用于诊断某些眼部疾病的这种方法和系统的用途。