(EN) The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H- chromen-4-one (TGR-1202). The present invention also relates to methods of preparing the same, pharmaceutical compositions containing them, and methods of treating a PI3K kinase mediated disease or disorder, such as cancer, by administering the same.
(ZH) 本发明涉及选择性PI3K δ抑制剂(S)‑2‑(1‑(4‑氨基‑3‑(3‑氟‑4‑异丙氧基苯基)‑1H‑吡唑并[3，4‑d]嘧啶‑1‑基)乙基)‑6‑氟‑3‑(3‑氟苯基)‑4H‑色烯‑4‑酮(TGR‑1202)的对甲苯磺酸盐(PTSA)的固态形式。本发明还涉及制备所述盐的方法，含有所述盐的药物组合物，及通过施用所述盐治疗PI3K激酶介导的疾病或病症，如癌症的方法。
