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1. CN106458839 - Prodrugs of succinic acid for increasing ATP production

Office
China
Application Number 201580024759.6
Application Date 08.04.2015
Publication Number 106458839
Publication Date 22.02.2017
Publication Kind A
IPC
C07C 69/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
40Succinic acid esters
C07C 69/708
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
708Ethers
C07D 319/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
C07D 321/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
321Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/-C07D319/174
02Seven-membered rings
04not condensed with other rings
061, 3-Dioxepines; Hydrogenated 1,3-dioxepines
C07D 323/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
323Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
C07D 273/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/-C07D271/183
02having two nitrogen atoms and only one oxygen atom
CPC
C07C 69/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
40Succinic acid esters
C07C 69/708
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
708Ethers
C07D 273/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
02having two nitrogen atoms and only one oxygen atom
C07D 281/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
18Eight-membered rings
C07D 307/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02not condensed with other rings
26having one double bond between ring members or between a ring member and a non-ring member
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32Oxygen atoms
33in position 2, the oxygen atom being in its keto or unsubstituted enol form
C07D 319/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
Applicants NEUROVIVE PHARMACEUTICAL AB
Inventors ELMER ESKIL
HANSSON MAGNUS JOAKIM
EHINGER KARL HENRIK JOHANNES
MOSS STEVEN
Priority Data PA201470187 08.04.2014 DK
Title
(EN) Prodrugs of succinic acid for increasing ATP production
(ZH) 用于增加ATP生产的琥珀酸的前药
Abstract
(EN) The invention discloses prodrugs of succinic acid for increasing ATP production. The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.
(ZH) 本发明提供了旨在增加在线粒体中的ATP生产的新的细胞可通透的琥珀酸酯以及细胞可通透的琥珀酸酯的前体。在真核细胞中产生和利用的ATP的主要部分源自线粒体氧化磷酸化,由克雷普斯循环向该过程提供高能电子。不是所有的克雷普斯循环中间物能够容易地透过细胞膜,其中之一是琥珀酸酯。设想提供新的细胞可通透的琥珀酸酯以允许穿过细胞膜,因此可以使用细胞可通透的琥珀酸酯以增强线粒体ATP输出。
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