(EN) The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.
(ZH) 本发明提供了旨在增加线粒体中ATP‑生产的新型的细胞可渗透的琥珀酸和细胞可渗透的琥珀酸前体。在真核细胞中生产和利用的ATP的主要部分来源于线粒体氧化磷酸化，一种通过克雷布斯循环向其提供高能电子的过程。并非所有的克雷布斯循环中间体容易渗透通过所述细胞膜，其中之一就是琥珀酸。提供的新型的细胞可渗透的琥珀酸设想为容许通过细胞膜，并且因此细胞可渗透的琥珀酸可以用于增强线粒体ATP‑输出。
