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1. CN105935352 - Method of making small liposomes

Office China
Application Number 102016000381865
Application Date 17.12.2009
Publication Number 105935352
Publication Date 14.09.2016
Publication Kind A
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A61K 9/127
A61K 38/17
A61K 39/00
CPC
C07F 9/10
A61K 9/1277
A61K 39/00
A61K 38/1735
Applicants ONCOTHYREON INC.
Inventors DUPUIT ROBERT A
REILLEY WILLIAM J
Priority Data 61/138353 17.12.2008 US
Title
(EN) Method of making small liposomes
(ZH) 制备小粒径脂质体的方法
Abstract
(EN)
Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.

(ZH)
制备具有特定粒径的脂质体,通过基本持续地混合基本上持续的水流和基本上持续的有机溶剂流,所述有机溶剂包含能形成脂质体的脂质,并冷却所述混合物以形成脂质体,控制水流流速对有机溶剂流的流速之比以及所述混合物的冷却速度以使获得至少约90%的脂质体的粒径小于约200nm。