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1. (CN105727298) 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法

Office : China
Application Number: 102016000108022 Application Date: 21.01.2011
Publication Number: 105727298 Publication Date: 06.07.2016
Publication Kind : A
IPC:
A61K 45/06
A61K 31/505
A61K 31/337
A61K 38/05
A61K 31/69
A61K 31/573
A61P 35/00
A61P 35/02
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
337
having four-membered rings, e.g. taxol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05
Dipeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
69
Boron compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573
substituted in position 21, e.g. cortisone, dexamethasone, prednisone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
CPC:
A61K 31/505
A61K 31/164
A61K 31/337
A61K 45/06
C07C 237/36
C07C 259/06
C07D 209/46
C07D 209/48
C07D 213/30
C07D 213/74
C07D 213/81
C07D 235/30
C07D 239/42
C07D 241/20
C07D 263/58
C07D 277/24
C07D 277/82
C07D 401/04
C07D 401/06
C07D 401/12
C07D 403/04
C07D 413/04
C07D 417/06
A61K 31/573
A61K 31/69
A61K 38/05
Applicants: 埃斯泰隆制药公司
Inventors: J·H·范杜泽尔
R·马齐茨夏克
W·奥吉尔
J·E·布拉德纳
黄国响
谢德建
郁楠
Agents: 北京市金杜律师事务所 11256
北京市金杜律师事务所 11256
Priority Data: 61/336,460 22.01.2010 US
Title: (ZH) 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法
Abstract:
(ZH) 一种作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法。本发明涉及一种新颖的包含锌螯合剂基团的“反向酰胺”化合物,和该化合物在抑制HDAC6和治疗各种与HDAC6有关的疾病、紊乱或病症中的应用。
Also published as:
RSP-2016/0849EP2526093IL221056JP2013518050SG182646CA2787756
EA201290677MX2012008553CL2012002026SG10201500444TKR1020120118480CN102933558
IL242867BR112012018246CN105753739JP2016153425NZ601655EP3091004
AU2011207289DK2526093ES2592278AU2016213729ID2013/01525PH1/2012/501492
TH151341IN1913/KOLNP/2012PT2526093WO/2011/091213