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1. CN105452265 - 用于治疗肿瘤性疾病尤其具有高HER2蛋白水平的肿瘤性疾病的他莫昔芬衍生物

Office
China
Application Number 201480033316.9
Application Date 07.04.2014
Publication Number 105452265
Publication Date 30.03.2016
Grant Number 105452265
Grant Date 10.05.2017
Publication Kind B
IPC
C07F 9/54
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9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
54Quaternary phosphonium compounds
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61K 31/662
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
662Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
CPC
C07F 9/5442
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9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P—C bonds
54Quaternary phosphonium compounds
5442Aromatic phosphonium compounds (P-C aromatic linkage)
C07F 9/5449
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9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P—C bonds
54Quaternary phosphonium compounds
5449Polyphosphonium compounds
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23Methine or polymethine dyes, e.g. cyanine dyes
0008substituted on the polymethine chain
C09B 23/141
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14Styryl dyes
141Bis styryl dyes containing two radicals C6H5-CH=CH-
C09B 69/001
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09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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69Dyes not provided for by a single group of this subclass
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C09B 69/008
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09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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69Dyes not provided for by a single group of this subclass
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Applicants 智脑公司
生物技术研究所
伊里·纽齐尔
KKCG股份公司
Inventors 伊里·纽齐尔
J·什图尔萨
L·维尔纳
Agents 北京派特恩知识产权代理有限公司 11270
北京派特恩知识产权代理有限公司 11270
Title
(ZH) 用于治疗肿瘤性疾病尤其具有高HER2蛋白水平的肿瘤性疾病的他莫昔芬衍生物
Abstract
(ZH) 本发明的主题是新颖的他莫昔芬的脂肪族三苯基鏻衍生物的靶向线粒体的E/Z异构体,其中脂肪族链为烷基或烯基,以及它们相应的叔胺盐和/或它们的混合物(MitoTAX)。他莫昔芬的烷基三苯基鏻衍生物具有通式(I),其中n=8至12以及其中Z选自有机盐或无机盐的组。他莫昔芬的烯基三苯基鏻衍生物具有通式IA,其中n=6至10以及其中Z具有以上所述含义。这些化合物可用于治疗肿瘤性疾病,尤其是具有高HER2蛋白水平的那些疾病。根据本发明的用于治疗肿瘤性疾病的药物含有具有通式(I)和/或IA的他莫昔芬的脂肪族三苯基鏻衍生物的至少一种E/Z异构体或它们相应的叔胺盐。
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