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1. CN102933558 - 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法

Office China
Application Number 201180015409.5
Application Date 21.01.2011
Publication Number 102933558
Publication Date 13.02.2013
Grant Number 102933558
Grant Date 16.03.2016
Publication Kind B
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
77
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
78
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C07D 239/42
C07C 233/78
A61K 31/505
A61P 35/00
A61P 25/00
CPC
A61K 31/337
A61K 31/505
A61K 31/573
A61K 31/69
A61K 38/05
A61K 45/06
Applicants 埃斯泰隆制药公司
Inventors J·H·范杜泽尔
R·马齐茨夏克
W·奥吉尔
J·E·布拉德纳
黄国响
谢德建
郁楠
Agents 北京市金杜律师事务所 11256
Priority Data 61/336,460 22.01.2010 US
Title
(ZH) 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法
Abstract
(ZH)

本发明涉及一种新颖的包含锌螯合剂基团的“反向酰胺”化合物,和该化合物在抑制HDAC6和治疗各种与HDAC6有关的疾病、紊乱或病症中的应用。