(EN) Impaired intraocular blood flow within vascular beds in the human eye are associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in one or more of the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions including, for example, the ocular disc, the temporal ellipse, the peripapillary retina, the peripapillary choroid, the macular retina, the macular choroid, the fovea avascular zone, and the area of non-perfusion. As described herein, a method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.
(ZH)
在人眼中血管床内的眼内血液流动的减少与某些眼部疾病相关联，所述眼部疾病例如包括青光眼、糖尿病性视网膜病变和年龄相关性黄斑变性。用于对各种眼内血管床的一个或多个中的血液流动量化的可靠方法可提供对眼部疾病病理生理学的血管组成的深入了解。利用超高速光学相干断层扫描(OCT)，开发出用于对不同眼内区域内的微循环进行成像的一种称为频谱分离幅度去相关血管造影(SSADA)的新的3D血管造影算法，所述眼内区域例如包括眼部视盘，颞椭圆，视乳头周围视网膜，视乳头周围脉络膜，黄斑视网膜，黄斑脉络膜，视网膜中央凹无血管区，以及无灌注区域。如本文所述，用于量化SSADA结果的方法被开发出来并用于检测早期眼部疾病中灌注的变化。本文还描述了与用于定量测量在不同眼内血管部位处的血液流动的方法相关的相关联实施例，用于实施这种方法的系统，以用于诊断某些眼部疾病的这种方法和系统的用途。
