CN104540822 Novel crystal form of dabrafenib mesylate and preparation method thereof

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Application Number 201480002089.3

Application Date 03.07.2014

Publication Number 104540822

Publication Date 22.04.2015

Grant Number 104540822

Grant Date 31.08.2016

Publication Kind B

IPC

CPC

Applicants 杭州普晒医药科技有限公司

Inventors 劳海萍
盛晓霞
盛晓红

Priority Data 2013102837054 08.07.2013 CN

Title

(EN) Novel crystal form of dabrafenib mesylate and preparation method thereof

(ZH) 达拉菲尼甲磺酸盐的晶型及其制备方法

Abstract

(EN) Disclosed are a novel crystal form of Dabrafenib mesylate and preparation method thereof. The novel crystal form of the present invention is more stable in water or an aqueous system, and has greater solubility and dissolution in water, thus having better stability and bioavailability compared with the existing crystal forms.

(ZH) 本发明涉及达拉菲尼甲磺酸盐的新晶型及其制备方法。本发明所述新晶型具有在水或含水体系中更稳定和水中溶解度、溶出量更大的优点，因此相对于现有的晶型，具有更好的稳定性和生物利用度。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
417	Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506	not condensed and containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
417	Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506	not condensed and containing further heterocyclic rings

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1. CN104540822 - Novel crystal form of dabrafenib mesylate and preparation method thereof