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1. (CA2747404) COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS

Office : Canada
Application Number: 2747404 Application Date: 17.12.2009
Publication Number: 2747404 Publication Date: 08.07.2010
Publication Kind : A1
Prior PCT appl.: Application Number:US2009068492 ; Publication Number: Click to see the data
IPC:
A61K 38/16
A61K 35/74
A61P 35/00
C12N 9/02
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02
Oxidoreductases (1.), e.g. luciferase
CPC:
A61K 45/06
A61K 38/164
C07K 14/21
Y02A 50/423
Applicants: CDG THERAPEUTICS, INC.
Inventors: DAS GUPTA, TAPAS
MEHTA, RAJENDRA G.
MEHTA, RAJESHWARI
BEATTIE, CRAIG
Priority Data: 12/337,167 17.12.2008 US
Title: (EN) COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS
(FR) COMPOSITIONS ET PROCEDES POUR LA PREVENTION DU CANCER AVEC DES CUPREDOXINES
Abstract:
(EN) The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at least one other chemopreventive agent. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The at least one other chemopreventive agent may comprise an antiestrogen such as Tamoxifen. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.


Also published as:
IL213657SG172195EP2379097JP2012512259CN102316887KR1020110126595
AU2009333174IN5232/DELNP/2011WO/2010/078042