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1. (CA2747182) METHOD OF MAKING SMALL LIPOSOMES

Office : Canada
Application Number: 2747182 Application Date: 17.12.2009
Publication Number: 2747182 Publication Date: 08.07.2010
Grant Number: Grant Date: 18.11.2014
Publication Kind : C
Prior PCT appl.: Application Number:PCTUS2009068499 ; Publication Number: Click to see the data
IPC:
A61K 9/127
C07K 14/775
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
775
Apolipopeptides
Applicants: ONCOTHYREON, INC.
Inventors:
Priority Data: 61/138,353 17.12.2008 US
Title: (EN) METHOD OF MAKING SMALL LIPOSOMES
(FR) PROCEDE DE FABRICATION DE PETITS LIPOSOMES
Abstract: front page image
(EN)



Liposomes of constrained particle size are prepared by substantially
continuously mixing substantially continuously
flowing streams of water, and of an organic solvent contain lipid(s) capable
of forming liposomes, and cooling the mixture so
liposomes form, the ratio of the flow rate of the stream of water to the flow
rate of the stream of organic solvent, and the rate of
cooling of said mixture, being controlled so as to obtain a preparation of
liposomes such that at least about 90% of the liposomes
are of a particle size less than about 200 nm.


Also published as:
EP2367532SG172257JP2012512260US20120034294CN102256595EA201100829
JP2014224127MX2011006562KR1020110094114CN105935352AU2009333177AU2013273711
IN2997/KOLNP/2011BRPI0923001WO/2010/078045