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1. (CA2745864) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS

Office : Canada
Application Number: 2745864 Application Date: 14.12.2009
Publication Number: 2745864 Publication Date: 01.07.2010
Publication Kind : A1
Prior PCT appl.: Application Number:EP2009067026 ; Publication Number: Click to see the data
IPC:
C07D 401/12
A61K 31/44
C07D 413/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
CPC:
C07D 401/12
C07D 413/12
Applicants: F.HOFFMANN-LA ROCHE AG
Inventors: BERGER, JACOB
CAROON, JOAN MARIE
KRAUSS, NANCY ELISABETH
LOPEZ-TAPIA, FRANCISCO JAVIER
WALKER, KEITH ADRIAN MURRAY
ZHAO, SHU-HAI
Priority Data: 61/203,482 23.12.2008 US
Title: (EN) DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
(FR) DIHYDROPYRIDONE AMIDES EN TANT QUE MODULATEURS DE P2X7
Abstract:
(EN) Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and R a are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.


Also published as:
AR074843IL213417MXMX/a/2011/006232SG172336EP2385939JP2012513433
CN102264723MX2011006232KR1020110086768AU2009331659IN4420/CHENP/2011WO/2010/072597