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1. (CA2745565) PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV

Office : Canada
Application Number: 2745565 Application Date: 22.12.2009
Publication Number: 2745565 Publication Date: 01.07.2010
Grant Number: Grant Date: 07.03.2017
Publication Kind : C
Prior PCT appl.: Application Number:PCTEP2009067715 ; Publication Number: Click to see the data
IPC:
C07D 311/06
C07D 417/04
C07D 453/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
06
with oxygen or sulfur atoms directly attached in position 2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
04
having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
CPC:
C07C 231/12
C07C 235/40
C07C 2601/08
C07D 307/33
C07D 417/04
C07D 453/04
C07C 67/475
Applicants: ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC
Inventors:
Priority Data: 08172691.1 23.12.2008 EP
Title: (EN) PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV
(FR) PROCEDES ET INTERMEDIAIRES POUR PREPARER UN INHIBITEUR MACROCYCLIQUE DE PROTEASE DU VHC
Abstract:
(EN)



The present invention relates to the cinchonidine salt useful in the
preparation of intermediates for preparing a
macrocyclic HCV inhibitor, as well as processes involving this salt.


Also published as:
AR074863IL213246MXMX/a/2011/006764EP2382198JP2012513381US20110257403
CN102264715RU2011130895ES2429013PT2382198MX2011006764US20150080577
KR1020110099048BRPI0923393RU0002588132DK2382198AU2009331530IN1505/MUMNP/2011
RU2016120007WO/2010/072742