CA2705508 NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

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Application Number 2705508

Application Date 12.11.2008

Publication Number 2705508

Publication Date 22.05.2009

Grant Number

Grant Date 24.01.2017

Publication Kind C

IPC

CPC

Applicants LABORATORIO FARMACEUTICO C.T. S.R.L.

Priority Data 07120551 13.11.2007 EP

Title

(EN) NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

(FR) NOUVELLES FORMES POLYMORPHES DE N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

Abstract

(EN)

Crystalline polymorphic forms of a compound of formula N-[4-
(trifluoromethyl)benzyl]-4-methoxybutyramide are
described. The two polymorphic forms, named polymorphic Form A and polymorphic
Form B, can be used in the treatment of drug
addiction and alcoholism and have very good stability. Methods for preparing
the polymorphic forms are also described.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
235	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02	having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04	the carbon skeleton being acyclic and saturated
06	having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
30	for treating abuse or dependence

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
235	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02	having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04	the carbon skeleton being acyclic and saturated
06	having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

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1. CA2705508 - NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200	Indexing scheme relating to specific properties of organic compounds
13	Crystalline forms, e.g. polymorphs