(EN)
The present invention provides tetrahydrouridine derivative compounds of
Formula I, or a
pharmaceutically acceptable salt thereof:
(see formula I)
wherein the carbon marked by an asterisk may have an (R) or an (S)
configuration; and wherein
R1 and R2 are fluoro.
The compounds of Formula I are inhibitors of the enzyme cytidine deaminase.
The invention
also provides the pharmaceutical compositions and kits comprising such
compounds, and
methods of making and using such compounds in the treatment of cancer.
