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1. (CA2646406) ANTI-IGF-IR ANTIBODIES AND USES THEREOF

Office : Canada
Application Number: 2646406 Application Date: 28.03.2007
Publication Number: 2646406 Publication Date: 08.11.2007
Publication Kind : A1
Prior PCT appl.: Application Number:US2007007664 ; Publication Number: Click to see the data
IPC:
C12N 15/13
A61K 39/395
A61K 47/48
A61P 35/00
C07K 16/28
C07K 19/00
C12P 21/08
C07K 14/72
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
72
for hormones
CPC:
C07K 16/2863
A61K 2039/505
C07K 2317/21
C07K 2317/24
C07K 2317/33
C07K 2317/34
C07K 2317/41
C07K 2317/52
C07K 2317/524
C07K 2317/53
C07K 2317/55
C07K 2317/73
C07K 2317/76
C07K 2317/77
C07K 2317/92
C07K 2319/00
Applicants: BIOGEN IDEC MA INC.
Inventors: HARIHARAN, KANDASAMY
GRAFF, CHRISTILYN
GLASER, SCOTT
GARBER, ELLEN
REYES, CHRISTOPHER L.
DEMAREST, STEPHEN
Priority Data: 60/786,347 28.03.2006 US
60/876,554 22.12.2006 US
Title: (EN) ANTI-IGF-IR ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-IGF-1R ET UTILISATIONS DE CEUX-CI
Abstract:
(EN) The invention relates to antibodies which bind to insulin like growth factor receptor -1 (IGF-IR) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-lR-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-I) and insulin like growth factor 2 (IGF-2) to bind to IGF-IR, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.


Also published as:
NO20084521NZ571964UAa200812599MXMX/a/2008/012146KR1020080113268SG146164
EP1999149JP2009532027IL194266CN101415728EA200802061AU2007245164
ID049.0429IN8061/DELNP/2008WO/2007/126876