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1. (CA2613551) USE OF CELLS FOR TREATING A NEURODEGENERATIVE CONDITION

Office : Canada
Application Number: 2613551 Application Date: 23.06.2006
Publication Number: 2613551 Publication Date: 04.01.2007
Grant Number: Grant Date: 20.06.2017
Publication Kind : C
Prior PCT appl.: Application Number:PCTUS2006024656 ; Publication Number: Click to see the data
IPC:
A61K 48/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants: TISSUEGENE, INC.
Inventors:
Priority Data: 60/595,342 23.06.2005 US
Title: (EN) USE OF CELLS FOR TREATING A NEURODEGENERATIVE CONDITION
(FR) UTILISATION DE CELLULES POUR TRAITER UN ETAT NEURODEGENERATIF
Abstract: front page image
(EN)
The present invention relates to prevention of nerve degeneration as there is
a need in
the art for a molecular neuroprotective compound and method of using such a
compound for
preventing the degradation of the neural system and neuronal cells. In one
embodiment, the
present invention is directed to the use of a population of cultured
connective tissue cells or
nerve cells transfected in vitro with a recombinant viral vector comprising a
DNA sequence
encoding a bone morphogenetic protein BMP operatively linked to a promoter,
for treating a
neurodegenerative condition of the central nervous system, or epilepsy, by
protecting nerves
from degeneration, wherein the transfected cells are injected to an area near
an injured nerve or
lesion in the central nervous system, such that expression of the DNA sequence
within the area
near the injured nerve causes attenuation of degeneration of the nerve.


Also published as:
KR1020080038310KR1020100074340EP1904113JP2009506982CN101232904JP2014088425
KR1020130101595KR1020140132010ES2562243KR1020160021458DK1904113CN106177996
AU2006261889AU2010257453IN10145/DELNP/2007KR1020180057737WO/2007/002512