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1. (CA2613162) HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS

Office : Canada
Application Number: 2613162 Application Date: 27.06.2006
Publication Number: 2613162 Publication Date: 04.01.2007
Publication Kind : A1
Prior PCT appl.: Application Number:GB2006002344 ; Publication Number: Click to see the data
IPC:
C07D 413/12
A61K 31/506
A61P 5/02
C07D 403/12
C07D 417/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
02
of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
CPC:
C07D 403/12
C07D 413/12
C07D 417/12
Applicants: TAKEDA CAMBRIDGE LIMITED
Inventors: SHOWELL, GRAHAM ANDREW
MILLER, DAVID JOHN
GLEN, ANGELA
CUBILLO DE DIOS, MARIA ANGELES
MERCHANT, KEVIN
MANDAL, AJAY KUMAR
Priority Data: 0513176.8 28.06.2005 GB
0521278.2 19.10.2005 GB
0608846.2 04.05.2006 GB
Title: (EN) HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS
(FR) ANTAGONISTES NON-PEPTIDES HETEROCYCLIQUES DE GNRH
Abstract:
(EN) A compound of formula (I): wherein either B is absent and A and Z are the same or different and are each hydrogen, halogen, alkyl, hydroxy, alkoxy, -CN, - C(Rc)2OH, -N(Rd)C(=X)Rc, -C(=X)N(Rc)(Rd), -S(O)m-Rc, -N(Rc)(Rd)S(O)2, - S(O)2N(Rc)(Rd), -N(Re)2, aryl optionally substituted with Ra or -O-aryl optionally substituted with Ra; or B is present and is -(CH2)n-, -C(Rb)2- or - O-, or B taken together with A or Z can be -C=C(Rb)-, -C(Rb)=C-, -CH2-CH(Rb)- or -CH(Rb)-CH2-; D is -O- or -S(O)m,-; E is a bond or is -(CH2)n-, -N(Rd)-, - (CH2)nN(Rd)- or -N(Rd)(CH2)n-; F is -C(=X)-; G is -(CH2)n-, -N(Rd)-, - (CH2)nN(Rd)- or -N(Rd)(CH2)n; J is a bond, -O-, -N(RC)C(=X)-, -C(=X)N(Rc)-, - S(O)m,-, -N(Rc)S(O)m-, -S(O)nN(Rc)-, -N(Re)- or -N(Rg)(Rh); K is a bond, alkylene, cycloalkylene, cycloalkenylene, arylene, heterocycloalkylene, heterocycloalkylene or heteroarylene; and L is hydrogen or a terminal group; has therapeutic utility.


Also published as:
EP1896465JP2008543965US20090209522WO/2007/000582