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1. (CA2610839) SELF-BUFFERING PROTEIN FORMULATIONS

Office : Canada
Application Number: 2610839 Application Date: 08.06.2006
Publication Number: 2610839 Publication Date: 28.12.2006
Grant Number: Grant Date: 25.06.2019
Publication Kind : C
Prior PCT appl.: Application Number:PCTUS2006022599 ; Publication Number: Click to see the data
IPC:
A61K 39/395
C07K 1/14
C07K 1/02
C07K 16/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
02
in solution
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
CPC:
A61K 39/3955
A61K 9/08
A61K 39/39591
A61K 47/02
A61K 47/10
A61K 47/26
C07K 16/00
C07K 16/241
C07K 16/2803
C07K 16/2827
C07K 16/2851
C07K 16/2866
C07K 16/2875
C07K 2317/21
C07K 2317/565
C07K 2317/94
Applicants: AMGEN INC.
Inventors:
Priority Data: 60/690,582 14.06.2005 US
Title: (EN) SELF-BUFFERING PROTEIN FORMULATIONS
(FR) PREPARATIONS DE PROTEINES A TAMPONNAGE SPONTANE
Abstract:
(EN)


The invention herein described, provides, among other things, self-buffering
protein formulations. Particularly, the invention provides self-buffering
pharmaceutical protein formulations that are suitable for veterinary and human
medical use. The self-buffering protein formulations are substantially free of
other buffering agents, stably maintain pH for the extended time periods
involved in the distribution and storage of pharmaceutical proteins for
veterinary and human medical use. The invention further provides methods for
designing, making, and using the formulation. In addition to other advantages,
the formulations avoid the disadvantages associated with the buffering agents
conventionally used in current formulations of proteins for pharmaceutical
use. The invention in these and other respects can be productively applied to
a wide variety of proteins and is particularly useful for making and using
self-buffering formulations of pharmaceutical proteins for veterinary and
medical use, especially, in particular, for the treatment of diseases in human
subjects.


Also published as:
MXMX/a/2007/015476KR1020080031684IL188102SG162788EP1909831ZA2008/00338
JP2008543839US20080311078BRPI0611901JP2013047261CN101217979EA200800050
JP2016053061AU2006259664AU2012272950AU2015242973AU2017202889IN5286/CHENP/2007
JP2018048196EP3351269WO/2006/138181