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1. CA2586415 - A METHOD FOR DETECTING CONFORMATIONAL CHANGE OF CALMODULIN, A METHOD FOR SCREENING A SUBSTANCE HAVING AN ACTIVITY THAT AFFECTS TO CONFORMATIONAL CHANGE OF CALMODULIN

Office
Canada
Application Number 2586415
Application Date 07.11.2005
Publication Number 2586415
Publication Date 18.05.2006
Publication Kind A1
IPC
G01N 19/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
19Investigating materials by mechanical methods
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
G01N 19/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
19Investigating materials by mechanical methods
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/6872
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
G01N 2333/4727
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4727Calcium binding proteins, e.g. calmodulin
Applicants FUENCE CO., LTD.
Inventors MOGAMI, KANAME
KASE, HIROSHI
Priority Data 2004325005 09.11.2004 JP
Title
(EN) A METHOD FOR DETECTING CONFORMATIONAL CHANGE OF CALMODULIN, A METHOD FOR SCREENING A SUBSTANCE HAVING AN ACTIVITY THAT AFFECTS TO CONFORMATIONAL CHANGE OF CALMODULIN
(FR) METHODE DE DETECTION DE LA MODIFICATION CONFORMATIONNELLE DE LA CALMODULINE ET METHODE DE CRIBLAGE DE SUBSTANCES DONT L'ACTIVITE A DES EFFETS SUR LA MODIFICATION CONFORMATIONNELLEDE LA CALMODULINE
Abstract
(EN) A method which can detect a calmodulin structure change easily and quantitatively in a short time and in real time, and a method which can retrieve effectively a matter having activity affecting a calmodulin structure change from among many matters. A matter under test from which activity is to be detected is allowed to act on a sample film consisting of calmodulin to detect changes in sample film tension and/or elasticity made after the matter under test is acted on by a mechanochemical sensor, whereby the method can measure, in real time and in a short time, activity that induces or blocks a calmodulin structure change provided by the matter under test.