CA2577513 CROSSLINKABLE POLY(OXYALKYLENE)-CONTAINING POLYAMIDE PREPOLYMERS

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Application Number 2577513

Application Date 21.11.2005

Publication Number 2577513

Publication Date 26.05.2006

Publication Kind A1

IPC

CPC

Applicants NOVARTIS AG

Inventors PHELAN, JOHN CHRISTOPHER

Priority Data 60/630,164 22.11.2004 US

Title

(EN) CROSSLINKABLE POLY(OXYALKYLENE)-CONTAINING POLYAMIDE PREPOLYMERS

(FR) POLYAMIDE PREPOLYMERES CONTENANT UN POLY(OXYALKYLENE) POUVANT ETRE RETICULE

Abstract

(EN) The present invention provides a water-soluble crosslinkable poly(oxyalkylene)~containing prepolymer. The crosslinkable poly(oxyalkylene)- containing copolymer prepolymer of the invention is prepared by reacting an amine-capped poly(oxyalkylene)~containing polyamide with a multifunctional compound having at least one one ethylenically unsaturated group and a function group coreactive with the capping amine groups of the amine-capped poly(oxyalkylene)-containing polyamide. The amine-capped poly(oxyalkylene)- containing polyamide is a copolymerization production of a mixture comprising: (a) at least one poly(oxyalkylene)diamine, (b) optionally at least one organic di~or poly-amine, (c) at least one dicarboxyl derivative, (d) optionally at least one polycarboxyl derivative, and (e) a carbodiimide. The crosslinkable poly(oxyalkylene)-containing prepolymer of the invention can find use in economically producing contact lenses which have improved thermal stability. In addition, the present invention provides method for making a medical device, preferably an ophthalmic device, more preferably a contact lens.

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G	MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69	Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
40	Polyamides containing oxygen in the form of ether groups

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
F	MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
8	Chemical modification by after-treatment
10	Acylation

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G	MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69	Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
48	Polymers modified by chemical after-treatment

G	PHYSICS
02	OPTICS
B	OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
1	Optical elements characterised by the material of which they are made; Optical coatings for optical elements
04	made of organic materials, e.g. plastics

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G	MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69	Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
40	Polyamides containing oxygen in the form of ether groups

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1. CA2577513 - CROSSLINKABLE POLY(OXYALKYLENE)-CONTAINING POLYAMIDE PREPOLYMERS

C	CHEMISTRY; METALLURGY
08	ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
L	COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
2203	Applications
02	for biomedical use