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1. CA2422353 - INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS

Office
Canada
Application Number 2422353
Application Date 05.09.2001
Publication Number 2422353
Publication Date 14.03.2003
Publication Kind A1
IPC
C07D 231/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring systems
56Benzopyrazoles; Hydrogenated benzopyrazoles
A61K 31/416
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
416condensed with carbocyclic ring systems, e.g. indazole
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07D 231/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring-systems
56Benzopyrazoles; Hydrogenated benzopyrazoles
Applicants BAYER AKTIENGESELLSCHAFT
Inventors WOLTERING, MICHAEL
HANING, HELMUT
SCHMIDT, GUNTER
PERNERSTORFER, JOSEF
BISCHOFF, HILMAR
KRETSCHMER, AXEL
VOHRINGER, VERENA
FAESTE, CHRISTIANE
Priority Data 10046029 18.09.2000 DE
Title
(EN) INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS
(FR) INDAZOLES A ACTION ANALOGUE A L'HORMONE THYROIDIENNE, LEUR PROCEDE DE FABRICATION ET LEUR UTILISATION DANS DES MEDICAMENTS
Abstract
(EN)
The invention relates to novel indazole derivatives of formula (I), in which Z represents O, S, CH2, CHF or CF2, and wherein R1-R7 have meanings as cited in Claim No. 1. The inventive indazole derivatives have an action similar to that of a thyroid hormone. The invention also relates to a method for producing said indazole derivatives, and to their use in medicaments.