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1. CA2079443 - BINDING OF GROWTH HORMONE TO LIPOSOMES

Office
Canada
Application Number 2079443
Application Date 30.10.1991
Publication Number 2079443
Publication Date 03.09.1992
Grant Number
Grant Date 31.12.2002
Publication Kind C
IPC
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 38/25
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
25Growth hormone-releasing factor (Somatoliberin)
CPC
A61K 9/1271
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Inventors MARGALIT, RIMONA
Priority Data 7/655,576 14.02.1991 US
Title
(EN) BINDING OF GROWTH HORMONE TO LIPOSOMES
(FR) LIAISON D'UNE HORMONE DE CROISSANCE ET DE LIPOSOMES
Abstract
(EN)
Crosslinking reagents glutaraldehyde and ethylene glycol diglycidyl ether have been used to bind epidermal growth factor ("EGF") to liposomal surfaces without utilizing the disulfide bridge linkage of EGF and, therefore, not adversely affecting the functionality of EGF. The crosslinking occurs through the amine residues offered by EGF and liposomes having phosphatidy- lethanolamine. The resulting EGF-modified liposomes offer potential as a microscopic drug delivery system.