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1. (CA2071224) QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE

Office : Canada
Application Number: 2071224 Application Date: 10.12.1990
Publication Number: 2071224 Publication Date: 27.06.1991
Grant Number: Grant Date: 09.04.2002
Publication Kind : C
Prior PCT appl.: Application Number:JP1990001617 ; Publication Number: Click to see the data
IPC:
C07D 215/38
A61K 31/47
A61K 31/54
C07D 405/12
C07D 417/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
CPC:
C07D 215/38
C07D 405/12
C07D 417/12
Applicants:
Inventors: MEGURO, KANJI
IKEDA, HITOSHI
Priority Data: 1/322172 11.12.1989 JP
Title: (EN) QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE
(FR) DERIVES DE LA QUINOLINE, LEUR OBTENTION ET LEUR UTILISATION
Abstract: front page image
(EN) A quinoline derivative of formula (I), wherein each phenyl ring of A and B can have one or more substituents; X is (II) (R1 is a hydrogen atom, a lower alkyl group or a lower alkoxy group) or (III) (R2 is a hydrogen atom or a lower alkyl group); Y is -(CH2)m-(m is 0, 1 or 2) or -CH = CH-, Z is a group of formulae (IV), (V) or (VI), wherein each phenyl ring of C and D can have one or more substituents, R3 and R4 are each a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, N,N-di-lower alkylcarbamoyloxy, optionally esterified carboxy or hydroxyl group, R5 is a halogen atom, or a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyloxy, N,N-di-lower alkylcarbamoyloxy, optionally esterified carboxy or hydroxyl group, R6 and R7 are each a hydrogen atom or a lower alkyl group, and n, o and p are each 1 or 2; 1 is 0 or 1; or its salt, which is useful as a drug for atherosclerosis.


Also published as:
EP0505565US5362742US5523407JPH06503550WO/1991/009017