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1. (CA2289115) RECOMBINANT ANTIBODY-ENZYME FUSION PROTEINS

Office : Canada
Application Number: 2289115 Application Date: 30.04.1998
Publication Number: 2289115 Publication Date: 12.11.1998
Publication Kind : A1
Prior PCT appl.: Application Number:US1998008840 ; Publication Number: Click to see the data
IPC:
C07K 16/00
A61K 39/395
A61K 47/48
C07H 21/02
C07H 21/04
C07K 16/30
C07K 17/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
17
Carrier-bound or immobilised peptides; Preparation thereof
CPC:
B82Y 5/00
A61K 47/6815
A61K 47/6865
A61K 47/6891
A61K 47/6899
A61K 2039/505
C07K 16/3053
C07K 2319/00
Y10S 530/866
Y10S 530/867
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: SIEMERS, NATHAN O.
YARNOLD, SUSAN
SENTER, PETER D.
Priority Data: 09/070,637 30.04.1998 US
60/045,888 07.05.1997 US
Title: (EN) RECOMBINANT ANTIBODY-ENZYME FUSION PROTEINS
(FR) PROTEINES FUSIONNEES D'ENZYMES ANTICORPS PRODUITES PAR RECOMBINAISON
Abstract:
(EN) The invention relates to recombinantly produced fusion polypeptides comprising antibody VH and VL sequences operatively linked to a .beta.-lactamase for use in the delivery of cytotoxic drugs to tumor cells.


Also published as:
EP0986576JP2002510968 AU1998072748WO/1998/050432