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1. (CA2288125) PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE

Office : Canada
Application Number: 2288125 Application Date: 28.04.1998
Publication Number: 2288125 Publication Date: 05.11.1998
Publication Kind : A1
Prior PCT appl.: Application Number:JP1998001939 ; Publication Number: Click to see the data
IPC:
C07C 59/84
C07C 51/06
C07C 51/377
C07D 209/34
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
76
containing keto groups
84
containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
06
from carboxylic acid amides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
347
by reactions not involving formation of carboxyl groups
377
by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32
Oxygen atoms
34
in position 2
CPC:
C07D 209/34
Applicants: MEDICAL INFORMATION SERVICES, INC.
Inventors: KONDO, HISAO
HIGASHIKAWA, TETSURO
KUBO, AKINORI
SAITO, NAOKI
Priority Data: 9/111236 28.04.1997 JP
9/209278 04.08.1997 JP
Title: (EN) PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE
(FR) PROCEDE SERVANT A PREPARER KETOPROFENE ET 5-BENZOYLE-3-METHYLE-2-INDOLINONE
Abstract:
(EN) A process for producing ketoprofen by benzoylating 3-methyl-2-indolinone with a benzoyl halide, cleaving the amido bond forming the five-membered ring moiety of the formed 5-benzoyl-3-methyl-2-indolinone with a basic compound and replacing an aromatic amino group of the formed compound with a hydrogen atom. A very high yield of ketoprofen can be obtained through ordinary steps, which are short as a whole, without using chemicals of an extremely high toxicity such as cyanides or chemicals of a low handleability, such as liquid ammonia.


Also published as:
KR1020010012131EP0990637JP3347745CN1253543WO/1998/049127