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1. (CA2064585) INHIBITION OF TUMOR GROWTH BY BLOCKADE OF THE PROTEIN C SYSTEM

Office : Canada
Application Number: 2064585 Application Date: 02.08.1990
Publication Number: 2064585 Publication Date: 05.02.1991
Grant Number: Grant Date: 27.04.1999
Publication Kind : C
Prior PCT appl.: Application Number:US1990004337 ; Publication Number: Click to see the data
IPC:
A61K 39/395
A61K 38/17
A61K 38/19
A61K 38/48
C07K 14/47
C07K 14/745
C07K 16/36
C07K 16/40
A61K 38/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
745
Blood coagulation or fibrinolysis factors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
36
against blood coagulation factors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
Inventors: ESMON, CHARLES T.
COMP, PHILIP C.
Priority Data: 389,617 04.08.1989 US
Title: (EN) INHIBITION OF TUMOR GROWTH BY BLOCKADE OF THE PROTEIN C SYSTEM
(FR) INHIBITION DE LA CROISSANCE TUMORALE PAR LE BLOCAGE DU SYSTEME PROTEIQUE C
Abstract: front page image
(EN) Composition, and methods of use thereof, for the inhibition of tumor growth and killing of tumors having extensive microcirculation wherein the active agent is a compound blocking the protein C system, preferably anti-protein C antibody, anti-protein S antibody and C4b binding protein. In the most preferred embodiment, the protein C blocking compound is provided in combination with a cytokine such as tumor necrosis factor (TNF), gamma interferon, interleukin-1, interleukin-2 and granulo-cytemacrophage colony stimulating factor. Example are provided demonstrating the administration of the protein C blocking compound, alone or in combination with TNF, to dogs having canine venereal tumors, a fibrosarcoma, and an adenocarcinoma, to pigs with melanoma, and a primate with a malignant lymphoma, followed by significant tumor reduction.


Also published as:
EP0489048JP7029937AU1990061643WO/1991/001753