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1. CA2245718 - NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS

Office
Canada
Application Number 2245718
Application Date 03.02.1997
Publication Number 2245718
Publication Date 07.08.1997
Publication Kind A1
IPC
C07D 295/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
20by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
A61K 31/495
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
C07D 211/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
10with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
16with acylated ring nitrogen atom
C07D 211/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
C07D 211/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
40Oxygen atoms
44attached in position 4
46having a hydrogen atom as the second substituent in position 4
Applicants PIERRE FABRE MEDICAMENT
Inventors CHOPIN, PHILIPPE
MARIEN, MARC
HALAZY, SERGE
PAUWELS, PETER
JORAND-LEBRUN, CATHERINE
Priority Data 9601273 02.02.1996 FR
Title
(EN) NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS
(FR) NOUVELLES PIPERAZINES AROMATIQUES DERIVEES DE CYCLOAZANES SUBSTITUES, AINSI QUE LEUR PROCEDE DE PREPARATION, LES COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION COMME MEDICAMENTS
Abstract
(FR)
La présente invention concerne les composés de formule (I) dans laquelle: R1 représente un hydrogène ou un alkyle linéaire ou ramifié comprenant de 1 à 6 atomes de carbone, Z2 représente O, NH, CH2O ou CH2NH, R2 et R3 identiques ou différents représentent un hydrogène ou un groupe choisi parmi un alkyle linéaire ou ramifié, un alcoxy, thioéther, nitrile, trifluorométhyle ou halogène (F, Cl, Br, I), ou, R2 et R3, lorsqu'ils sont adjacents, pris ensemble, forment un cycle à 5 ou 6 chaînons de façon à constituer par exemple un naphtyle, un tétrahydronaphtyle, un benzopyrane ou un benzodioxane, X-Y représente NCH2, CH-CH2, C=CH, N ou NCH2CH2, Z1 représente -(CH2)n, -(CH2)n CO- , -CO-, -CO(CH2)n-, -SO2-, -SO2(CH2)n-, -O(CH2)n-, -O(CH2)nCO-, -OCO-, - NH(CH2)n-, -NH(CH2)nCO-, -NHCO-, -NHCO(CH2)n-, -NH(CH2)nSO2-, -NHSO2-, - NHSO2(CH2)n-, -CH=CHCO-, -CCCO- -(CH2)nSO2-, -O(CH2)nSO2-.