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1. (CA2067816) MUSCARINIC RECEPTOR ANTAGONISTS

Office : Canada
Application Number: 2067816 Application Date: 28.11.1990
Publication Number: 2067816 Publication Date: 13.06.1991
Grant Number: Grant Date: 25.03.1997
Publication Kind : C
Prior PCT appl.: Application Number:EP1990002042 ; Publication Number: Click to see the data
IPC:
C07D 401/04
A61K 31/445
C07D 401/14
C07D 405/14
C07D 409/14
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
CPC:
C07D 401/04
C07D 405/14
Applicants:
Inventors: MACKENZIE, ALEXANDER RODERICK
CROSS, PETER EDWARD
Priority Data: 8928041.6 12.12.1989 GB
Title: (EN) MUSCARINIC RECEPTOR ANTAGONISTS
(FR) ANTAGONISTES DES RECEPTEURS MUSCARINIQUES
Abstract: front page image
(EN) A muscarinic receptor antagonist of formula (I) or a pharmaceutically acceptable salt thereof, wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; and R1 is a group of formulae (a), (b), (c) or Het where R2 and R3 are each independ- ently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)nOH, halo, trifluoromethyl cyano, -(CH2)nNR4R5, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), -CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl)2, -SO2NH2, -(CH2)nCONR4R5 or -(CH2)nCOO(C1-C4 al- kyl);R4 and R5 are each independently H or C1-C4 alkyl; n is 0, 1 or 2; X and X1 are each independently O or CH2; m is 1, 2 or 3; and "Het" is pyridyl, pyrazinyl or thienyl. The compounds are particularly useful in the treatment of irritable bowel syndrome.


Also published as:
FI922344EP0505377ES2082013US5281601JPH05501555DE000069024663
PT96143DK0505377WO/1991/009015