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1. (CA3005386) METHOD FOR DETERMINING CELL CLONALITY

Office : Canada
Application Number: 3005386 Application Date:
Publication Number: 3005386 Publication Date: 08.06.2017
Publication Kind : A1
Prior PCT appl.: Application Number:PCTEP2016079427 ; Publication Number: Click to see the data
IPC:
C12Q 1/68
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: ARES TRADING S.A.
Inventors:
Priority Data: 15197894.7 03.12.2015 EP
Title: (EN) METHOD FOR DETERMINING CELL CLONALITY
(FR) METHODE DE DETERMINATION DE LA CLONALITE CELLULAIRE
Abstract: front page image
(EN) The invention relates to a method for determining the clonality of a master cell bank (MCB) in which a transgene has been inserted. The method involves a combination of sequencing methodology and bioinformatic analysis, performed on multiple subclones originating from a common MCB, to establish a reliable set of reference transgene insertion regions in one reference subclone, and corresponding sets of comparative transgene insertion regions in one or more other subclones originating from the same MCB. Based on the degree of congruity between reference and comparative transgene insertion regions, the MCB is determined to be either monoclonal or polyclonal.


Also published as:
AU2016363746CN108368549KR1020180088867EP3384045US20180327830IL259750
WO/2017/093400